Teams trending in opposite directions meet when the take on the in an interleague matchup on Friday afternoon. The White Sox (63-46), first in the American League Central, have opened up a 9.5 game lead over Wayne Gretzky Jersey the second-place . The Cubs (52-58), fourth in the National League Central, are 3-7 in their last 10 games after trading away several of their best players at the trade deadline. The teams split six games a year ago. This will be their first meeting of 2021.First pitch from Wrigley Field is set for 2:20 p.m. ET. The White Sox lead the all-time series 69-65, including a 35-32 edge in games played on the north side. The White Sox are a -172 favorite on the money line in the latest White Sox vs. Cubs odds from Caesars Sportsbook, while the over-under for total runs scored is nine. Before making any Cubs vs. White Sox picks, .This model, which simulates every pitch of every game 10,000 times, is a profitable 140-113 on top-rated through 18 weeks in the 2021 season. It also had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line picks. Anyone following it has seen some huge returns.Now, the model has dialed in on and revealed its predictions and best bets. . Here are Andrew Ference Jersey the and betting trends for Cubs vs. White Sox: White Sox vs. Cubs money line: White Sox -172, Cubs +157White Sox vs. Cubs run line: White Sox -1.5White Sox vs. Cubs over-under: 9 runsCWS: The White Sox are 50-22 in their last 72 games as a favoriteCHI: The Cubs are 15-6 in their last 21 home games against a team with a winning record Featured Game | Chicago Cubs vs. Chicago White Sox Moneyline Spread Total CHC CHW Why you should back Ryan Nugent-Hopkins Jersey the White SoxThe White Sox are expected to send right-hander (10-3, 2.07 ERA) to the mound. Lynn has allowed three runs or fewer in each of his last seven starts. His worst start in that stretch was his last one when he faced the Cleveland Indians on July 30. In that game, he allowed three earned runs on seven hits in five innings. He walked one and struck out seven and received a no-decision. In the start prior, he shut down the NL Central-leading by allowing Nail Yakupov Jersey just one earned run on six hits in six innings.Offensively, first baseman has hits in four of his last five games. He is batting .245 with 20 homers, 82 RBIs and 53 runs scored in 102 games on the season. He has hit well against the Cubs. In 30 career games against them, Abreu is batting .348 with seven doubles, 10 homers and 25 RBIs. He also enjoys hitting at Wrigley Field, where he is a .317 lifetime hitter with three doubles, six homers and 14 RBIs.Why you should back the CubsThe Cubs are expected to start right-hander (13-4, 3.71 ERA). Zack Kassian Jersey Hendricks has won 11 consecutive decisions and is coming off a win at Washington in his last outing. In that game, he allowed one earned run on four hits in seven innings. He is just 1-4 in eight career starts against the White Sox, but has a respectable 3.74 ERA. He has walked just eight against 39 strikeouts. Since the Cubs' trade deadline moves, third baseman has taken advantage of his playing time. He has hits in eight of his last 10 games, including Andrej Sekera Jersey a 3-for-4 performance at Colorado on Wednesday. In that game, he doubled and drove in three runs. For the season, he is batting .272 with 16 homers, 32 RBIs and 31 runs scored.How to make Cubs vs. White Sox picksSportsLine's model is leaning under on the run total, as the simulation projects the teams to combine for eight runs. It also says one side of the money line has the value. .So who wins White Sox vs. Cubs? And which side of the money line has all the value? , all from the advanced model that has been profitable on picks in 2021, and find out.